PerspectiveImmunology

Therapeutic Manipulation of Gut Flora

Science  25 Aug 2000:
Vol. 289, Issue 5483, pp. 1311-1312
DOI: 10.1126/science.289.5483.1311

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Summary

In developed countries as many as two individuals in every thousand suffer from inflammatory bowel disease (ulcerative colitis and Crohn's disease). In his Perspective, Shanahan discusses a new therapeutic approach to treating these conditions in which bacteria normally found in the gut are engineered to produce the anti-inflammatory cytokine interleukin-10 and then are fed as probiotics to mice with these disorders ( Steidler et al.).

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