Genomics Happens

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Science  01 Sep 2000:
Vol. 289, Issue 5484, pp. 1488-1489
DOI: 10.1126/science.289.5484.1488

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Cholera has been the scourge of humankind for centuries. Although most of the time Vibrio cholerae, the microbe that causes this disease, is a free-living organism inhabiting aquatic environments, it can invade human hosts causing severe diarrhea and often death. As DiRita explains in his Perspective, sequencing of the entire V. cholerae genome is revealing new facets of the pathogenesis of this dangerous microbe.