On the Ancestry of Barrels

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Science  01 Sep 2000:
Vol. 289, Issue 5484, pp. 1490
DOI: 10.1126/science.289.5484.1490

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Most proteins consist of several domains linked together in a single polypeptide chain, and many of these proteins have evolved by gene duplication and fusion. Miles and Davies discuss the study by Lang et al., who show that this type of protein evolution may also occur in b/a barrel proteins, a common single-domain protein fold. Other single domain proteins may have arisen from similar evolutionary mechanisms.