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Structural Evidence for Evolution of the β/α Barrel Scaffold by Gene Duplication and Fusion

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Science  01 Sep 2000:
Vol. 289, Issue 5484, pp. 1546-1550
DOI: 10.1126/science.289.5484.1546

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Abstract

The atomic structures of two proteins in the histidine biosynthesis pathway consist of β/α barrels with a twofold repeat pattern. It is likely that these proteins evolved by twofold gene duplication and gene fusion from a common half-barrel ancestor. These ancestral domains are not visible as independent domains in the extant proteins but can be inferred from a combination of sequence and structural analysis. The detection of subdomain structures may be useful in efforts to search genome sequences for functionally and structurally related proteins.

  • * To whom correspondence should be addressed. E-mail: wilmanns{at}embl-hamburg.de

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