RNA Editing AIDs Antibody Diversification?

Science  08 Sep 2000:
Vol. 289, Issue 5485, pp. 1705-1706
DOI: 10.1126/science.289.5485.1705

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How do B cells generate the enormous diversity of antibodies that are able to recognize and bind to whichever antigen a B cell might happen to encounter in the body? Several genetic mechanisms that manipulate different combinations of immunoglobulin genes are known. In their Perspective, Neuberger and Scott, highlight another genetic mechanism called RNA editing now shown to be involved in the production of antibody diversity.