Report

Subgroup of Reproductive Functions of Progesterone Mediated by Progesterone Receptor-B Isoform

Science  08 Sep 2000:
Vol. 289, Issue 5485, pp. 1751-1754
DOI: 10.1126/science.289.5485.1751

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Abstract

Progesterone regulates reproductive function through two intracellular receptors, progesterone receptor–A (PR-A) and progesterone receptor–B (PR-B), that arise from a single gene and function as transcriptional regulators of progesterone-responsive genes. Although in vitro studies show that PR isoforms can display different transcriptional regulatory activities, their physiological significance is unknown. By selective ablation of PR-A in mice, we show that the PR-B isoform modulates a subset of reproductive functions of progesterone by regulation of a subset of progesterone-responsive target genes. Thus, PR-A and PR-B are functionally distinct mediators of progesterone action in vivo and should provide suitable targets for generation of tissue-selective progestins.

  • * To whom correspondence should be addressed. E-mail: orlac{at}bcm.tmc.edu

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