News of the WeekMolecular Biology

Cancer Fighter's Modus Operandi Revealed

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Science  15 Sep 2000:
Vol. 289, Issue 5486, pp. 1857-1859
DOI: 10.1126/science.289.5486.1857

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Researchers have deciphered how a promising cancer drug acts like a smart bomb, homing in on only a very narrow range of its potential targets in the cell. The compound, known as STI-571, has shown remarkable success in early clinical trials on patients with chronic myelogenous leukemia. Now, in work reported on page 1938, scientists reveal just how the compound works--information that could aid in the design of similar cancer therapies.