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Signal Transduction Through Prion Protein

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Science  15 Sep 2000:
Vol. 289, Issue 5486, pp. 1925-1928
DOI: 10.1126/science.289.5486.1925

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Abstract

The cellular prion protein PrPc is a glycosylphosphatidylinositol-anchored cell-surface protein whose biological function is unclear. We used the murine 1C11 neuronal differentiation model to search for PrPc-dependent signal transduction through antibody-mediated cross-linking. A caveolin-1–dependent coupling of PrPc to the tyrosine kinase Fyn was observed. Clathrin might also contribute to this coupling. The ability of the 1C11 cell line to trigger PrPc-dependent Fyn activation was restricted to its fully differentiated serotonergic or noradrenergic progenies. Moreover, the signaling activity of PrPc occurred mainly at neurites. Thus, PrPc may be a signal transduction protein.

  • * To whom correspondence should be addressed. E-mail: srichard{at}pasteur.fr

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