Ubiquitination--More Than Two to Tango

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Science  22 Sep 2000:
Vol. 289, Issue 5487, pp. 2061-2062
DOI: 10.1126/science.289.5487.2061

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The ubiquitin pathway in the cell is an elegant system for targeting unwanted proteins for degradation. Three enzymes, E1, E2, and E3, are responsible for attaching the ubiquitin tag to proteins destined to be chopped up. In their Perspective, Joazeiro and Hunter discuss new structural findings that reveal the part played by an E3 called c-Cbl in this ubiquitinating process.