PerspectiveBiochemistry

Ubiquitination--More Than Two to Tango

Science  22 Sep 2000:
Vol. 289, Issue 5487, pp. 2061-2062
DOI: 10.1126/science.289.5487.2061

You are currently viewing the summary.

View Full Text

Via your Institution

Log in through your institution

Log in through your institution


Summary

The ubiquitin pathway in the cell is an elegant system for targeting unwanted proteins for degradation. Three enzymes, E1, E2, and E3, are responsible for attaching the ubiquitin tag to proteins destined to be chopped up. In their Perspective, Joazeiro and Hunter discuss new structural findings that reveal the part played by an E3 called c-Cbl in this ubiquitinating process.

Related Content