PerspectiveAging

Aging, Chromatin, and Food Restriction--Connecting the Dots

+ See all authors and affiliations

Science  22 Sep 2000:
Vol. 289, Issue 5487, pp. 2062-2063
DOI: 10.1126/science.289.5487.2062

You are currently viewing the summary.

View Full Text

This article has a correction. Please see:

Summary

Model organisms such as yeast have proved exceptionally valuable for revealing new information about the molecular pathways involved in the aging of cells. In her Perspective, Campisi comments on new work showing that caloric restriction increases longevity in yeast by activating the SIR2 gene, which alters the compactness of chromatin and thus regulates gene expression ( Lin et al.).