DATABASES: Cancer Clues

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Science  29 Sep 2000:
Vol. 289, Issue 5488, pp. 2235
DOI: 10.1126/science.289.5488.2235c

Tumor cell chromosomes often bear telltale alterations that provide clues to the genetic and cellular pathways leading to uncontrolled growth. Last week, the Cancer Genome Anatomy Project and John Wiley & Sons Inc. put a key resource on these chromosomal changes on a free Web site. Compiled by Swedish researchers over the past 17 years, the Mitelman Database of Chromosome Aberrations in Cancer holds data on karyotype (abnormalities in chromosomes) for over 35,000 human cancer cases. Linked to MEDLINE abstracts, the database can be searched by terms such as organ, morphology, country, and race.

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