Protein Loss in Cancer Cachexia

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Science  29 Sep 2000:
Vol. 289, Issue 5488, pp. 2293-2294
DOI: 10.1126/science.289.5488.2293

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Muscle wasting (cachexia) is a debilitating syndrome that is common in AIDS and cancer patients. In his Perspective, Tisdale explores exciting new findings ( Guttridge et al.) showing that the master transcription factor NF-kB decreases the expression of MyoD, a transcription factor involved in the differentiation of muscle stem cells in response to damage or wasting of skeletal muscle. This work opens up new therapeutic strategies for the treatment of this life-threatening syndrome.