An Accomplice for γ-Secretase Brought into Focus

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Science  29 Sep 2000:
Vol. 289, Issue 5488, pp. 2296-2297
DOI: 10.1126/science.289.5488.2296

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The presenilin proteins are mutated in some patients with early onset Alzheimer's disease, but the function of these proteins is not known. Accumulating evidence suggests that they are g-secretase enzymes that process the amyloid precursor protein. Now, as Sisodia discusses in this Perspective, another protein called nicastrin has been discovered that may contribute to the g-secretase activity of the presenilins.