A Calmodulin-Related Protein That Suppresses Posttranscriptional Gene Silencing in Plants

See allHide authors and affiliations

Science  06 Oct 2000:
Vol. 290, Issue 5489, pp. 142-144
DOI: 10.1126/science.290.5489.142

You are currently viewing the abstract.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution


Posttranscriptional gene silencing (PTGS) is an ancient eukaryotic regulatory mechanism in which a particular RNA sequence is targeted and destroyed. The helper component–proteinase (HC-Pro) of plant potyviruses suppresses PTGS in plants. Using a yeast two-hybrid system, we identified a calmodulin-related protein (termed rgs-CaM) that interacts with HC-Pro. Here we report that rgs-CaM, like HC-Pro itself, suppresses gene silencing. Our work is the first report identifying a cellular suppressor of PTGS.

  • * These authors contributed equally to this report.

  • To whom correspondence should be addressed. E-mail: vance{at}

View Full Text