Report

A Calmodulin-Related Protein That Suppresses Posttranscriptional Gene Silencing in Plants

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Science  06 Oct 2000:
Vol. 290, Issue 5489, pp. 142-144
DOI: 10.1126/science.290.5489.142

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Abstract

Posttranscriptional gene silencing (PTGS) is an ancient eukaryotic regulatory mechanism in which a particular RNA sequence is targeted and destroyed. The helper component–proteinase (HC-Pro) of plant potyviruses suppresses PTGS in plants. Using a yeast two-hybrid system, we identified a calmodulin-related protein (termed rgs-CaM) that interacts with HC-Pro. Here we report that rgs-CaM, like HC-Pro itself, suppresses gene silencing. Our work is the first report identifying a cellular suppressor of PTGS.

  • * These authors contributed equally to this report.

  • To whom correspondence should be addressed. E-mail: vance{at}biol.sc.edu

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