NO More than Needed

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Science  13 Oct 2000:
Vol. 290, Issue 5490, pp. 233
DOI: 10.1126/science.290.5490.233a

Nitric oxide (NO) is implicated in many physiological processes. Hou et al. have developed a method that allows controlled generation of nanomolar amounts of NO. Their approach is based on self-assembled monolayers of organic compounds that contain an NO donor and that are bound to a gold electrode via a thiol linkage. When an electric potential is applied, one-electron electrochemical oxidation leads to the release of NO. The relationship between the amount of NO generated and the area of the electrode was found to be linear, indicating that the amount of released NO could be controlled easily by selecting an appropriately sized electrode surface area. This approach may be used in microelectrode arrays for biochemical applications. — JU

Chem. Comm. 2000, 1831 (2000).

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