Twist and Fluoresce

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Science  13 Oct 2000:
Vol. 290, Issue 5490, pp. 286-287
DOI: 10.1126/science.290.5490.286

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Catalytic antibodies, or artificial enzymes, act as catalysts by lowering the energy of the transition state of a reaction. In his Perspective, Brauman highlights the study by Simeonov et al., who have applied similar principles to photochemical processes and shown that intense fluorescence can be achieved. The approach provides a way of measuring internal molecular motion within the antibody on a very fast time scale. Fluorescent antibodies may find applications in immunochemistry, histological assays, and genomic studies.