Report

Learning-Induced LTP in Neocortex

Science  20 Oct 2000:
Vol. 290, Issue 5491, pp. 533-536
DOI: 10.1126/science.290.5491.533

You are currently viewing the abstract.

View Full Text

Via your Institution

Log in through your institution

Log in through your institution


Abstract

The hypothesis that learning occurs through long-term potentiation (LTP)– and long-term depression (LTD)–like mechanisms is widely held but unproven. This hypothesis makes three assumptions: Synapses are modifiable, they modify with learning, and they strengthen through an LTP-like mechanism. We previously established the ability for synaptic modification and a synaptic strengthening with motor skill learning in horizontal connections of the rat motor cortex (MI). Here we investigated whether learning strengthened these connections through LTP. We demonstrated that synapses in the trained MI were near the ceiling of their modification range, compared with the untrained MI, but the range of synaptic modification was not affected by learning. In the trained MI, LTP was markedly reduced and LTD was enhanced. These results are consistent with the use of LTP to strengthen synapses during learning.

  • * To whom correspondence should be addressed. E-mail: mengia_rioult{at}brown.edu

View Full Text

Related Content