Combating Parkinson's Disease--Step Three

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Science  27 Oct 2000:
Vol. 290, Issue 5492, pp. 721-724
DOI: 10.1126/science.290.5492.721

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The degeneration of dopamine neurons in the nigrostriatal pathway of the brain results in the debilitating motor deficits of Parkinson's disease. In a Perspective, Olson discusses a new study ( Kordower et al.) demonstrating that injection of a lentiviral vector containing the gene encoding GDNF (a trophic factor for dopamine neurons) into the nigrostriatal pathway of monkeys with PD prevents neuronal loss and reverses some of the motor deficits of this disease.