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Genomic Analysis of Gene Expression in C. elegans

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Science  27 Oct 2000:
Vol. 290, Issue 5492, pp. 809-812
DOI: 10.1126/science.290.5492.809

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Abstract

Until now, genome-wide transcriptional profiling has been limited to single-cell organisms. The nematodeCaenorhabditis elegans is a well-characterized metazoan in which the expression of all genes can be monitored by oligonucleotide arrays. We used such arrays to quantitate the expression of C. elegans genes throughout the development of this organism. The results provide an estimate of the number of expressed genes in the nematode, reveal relations between gene function and gene expression that can guide analysis of uncharacterized worm genes, and demonstrate a shift in expression from evolutionarily conserved genes to worm-specific genes over the course of development.

  • * To whom correspondence should be addressed. E-mail: ahill{at}genetics.com (A.A.H.) and hunter{at}mcb.harvard.edu(C.P.H.)

  • Present address: Millennium Predictive Medicine, 700 One Kendall Square, Third Floor, Cambridge, MA 02139, USA.

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