Chemistry

Bound to Cooperate

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Science  03 Nov 2000:
Vol. 290, Issue 5493, pp. 901
DOI: 10.1126/science.290.5493.901b

Dendrimers are large, globular molecules fabricated from branching polymers that are attached to a central core. They are ideally suited for molecular recognition, the incorporation of guest molecules, and catalysis, particularly because they can be readily isolated after reaction through precipitation or filtration. Cooperative binding to dendrimer surface units has previously been demonstrated. Breinbauer and Jacobsen now show that a commercially available dendrimer, whose surfaces were modified with a known cobalt catalyst, not only was catalytically active but that its activity was dramatically enhanced relative to monomeric and dimeric constructs. Such cooperative effects on catalysis may result from the restricted conformations imposed by the dendrimer structure. — JU

Angew. Chem. Int. Ed.39, 3604 (2000).

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