Isomer-Specific Dephosphorylation

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Science  10 Nov 2000:
Vol. 290, Issue 5494, pp. 1055
DOI: 10.1126/science.290.5494.1055c

The protein Pin1 is an isomerase that catalyzes interconversion of cis and trans forms of proline in polypeptides and is thought to function in signaling pathways that control cell division. Zhou et al. propose a mechanism by which Pin1 might influence signaling through such pathways. They report that the proline-directed phosphatase known as protein phosphatase 2A (PP2A) is stereospecific and dephosphorylates only trans phosphoSer- or phosphoThr-Pro peptides; Pin1 may function to facilitate dephosphorylation of potential PP2A substrates by promoting cis-trans isomerization. Consistent with this possibility, genetic evidence indicates that overexpression of Pin1 can partially overcome defects caused by conditional mutations in PP2A, and defects from loss of Pin1 function are reduced in cells overexpresssing PP2A. — LBR

Mol. Cell6, 873 (2000).

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