Artificial Chromosomes Coming to Life

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Science  17 Nov 2000:
Vol. 290, Issue 5495, pp. 1308-1309
DOI: 10.1126/science.290.5495.1308

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One of the biggest obstacles to gene therapy is the delivery of the therapeutic gene to the target tissue so that it is appropriately expressed. In his Perspective, Willard looks at the potential advantages of using a human artificial chromosome to maintain expression of a therapeutic gene and discusses some of the hurdles yet to be overcome before this gene delivery system can be tried out in the clinic.