PerspectiveGENOMICS AND GENE THERAPY

Artificial Chromosomes Coming to Life

See allHide authors and affiliations

Science  17 Nov 2000:
Vol. 290, Issue 5495, pp. 1308-1309
DOI: 10.1126/science.290.5495.1308

You are currently viewing the summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

Summary

One of the biggest obstacles to gene therapy is the delivery of the therapeutic gene to the target tissue so that it is appropriately expressed. In his Perspective, Willard looks at the potential advantages of using a human artificial chromosome to maintain expression of a therapeutic gene and discusses some of the hurdles yet to be overcome before this gene delivery system can be tried out in the clinic.