PerspectiveSignal Transduction

An Arresting Start for MAPK

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Science  24 Nov 2000:
Vol. 290, Issue 5496, pp. 1515-1518
DOI: 10.1126/science.290.5496.1515

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Summary

Exactly how signaling proteins know where they need to be in the cell is one of the intriguing mysteries of signal transduction biology. In a Perspective, Pouysségur reviews new results that identify b-arrestin 2 as a scaffolding protein that holds together the different components of a MAPK signaling pathway that activates the transcription factor kinase, JNK3.