Report

Down-Regulation of the Macrophage Lineage Through Interaction with OX2 (CD200)

+ See all authors and affiliations

Science  01 Dec 2000:
Vol. 290, Issue 5497, pp. 1768-1771
DOI: 10.1126/science.290.5497.1768

You are currently viewing the abstract.

View Full Text

Via your Institution

Log in through your institution

Log in through your institution


Abstract

OX2 (CD200) is a broadly expressed membrane glycoprotein, shown here to be important for regulation of the macrophage lineage. In mice lacking CD200, macrophage lineage cells, including brain microglia, exhibited an activated phenotype and were more numerous. Upon facial nerve transection, damaged CD200-deficient neurons elicited an accelerated microglial response. Lack of CD200 resulted in a more rapid onset of experimental autoimmune encephalomyelitis (EAE). Outside the brain, disruption of CD200-CD200 receptor interaction precipitated susceptibility to collagen-induced arthritis (CIA) in mice normally resistant to this disease. Thus, in diverse tissues OX2 delivers an inhibitory signal for the macrophage lineage.

  • * To whom correspondence should be addressed. E-mail: jon.sedgwick{at}dnax.org

View Full Text

Related Content