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Turning Blood into Brain: Cells Bearing Neuronal Antigens Generated in Vivo from Bone Marrow

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Science  01 Dec 2000:
Vol. 290, Issue 5497, pp. 1779-1782
DOI: 10.1126/science.290.5497.1779

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Abstract

Bone marrow stem cells give rise to a variety of hematopoietic lineages and repopulate the blood throughout adult life. We show that, in a strain of mice incapable of developing cells of the myeloid and lymphoid lineages, transplanted adult bone marrow cells migrated into the brain and differentiated into cells that expressed neuron-specific antigens. These findings raise the possibility that bone marrow–derived cells may provide an alternative source of neurons in patients with neurodegenerative diseases or central nervous system injury.

  • * To whom correspondence should be addressed. E-mail: mezey{at}codon.nih.gov

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