Combinatorial libraries of molecules, once synthesized, usually are static, but the facile interconversion of some chemical species makes it feasible to design dynamic combinatorial libraries (DCLs), so-called because the composition of these libraries can be altered after synthesis. Otto et al. show that disulfide exchange reactions are a promising route for constructing DCLs. Several dithiol compounds were reacted in air at pH 7.5 to create macrocyclic compounds. Analysis by mass spectrometry revealed the presence of more than 100 macrocycles, and the time course of DCL growth could be assessed by using acidic conditions to inhibit disulfide exchange. These macrocyclic adducts could find application as synthetic receptors or as ionophores. — PDS
J. Am. Chem. Soc., in press.