PerspectiveCell Biology

Actin' Up with Rac1

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Science  08 Dec 2000:
Vol. 290, Issue 5498, pp. 1902-1903
DOI: 10.1126/science.290.5498.1902

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The elegant architecture of photoreceptor cells in the retina is dependent on organization of the actin cytoskeleton during eye development. But what drives this organization? In an equally elegant Perspective, Colley explains new findings in fruit flies (Chang and Ready) that point to the photopigment rhodopsin and its signaling molecule the Rho GTPase Drac1 as the orchestrators of actin organization and the consequent assembly of the sensory membrane in the photoreceptor cell.