Multigenerational Cortical Inheritance of the Rax2 Protein in Orienting Polarity and Division in Yeast

See allHide authors and affiliations

Science  08 Dec 2000:
Vol. 290, Issue 5498, pp. 1975-1978
DOI: 10.1126/science.290.5498.1975

You are currently viewing the abstract.

View Full Text


Diploid yeast cells repeatedly polarize and bud from their poles, probably because of highly stable marks of unknown composition. Here, Rax2, a membrane protein, was shown to behave as such a mark. The Rax2 protein itself was inherited immutably at the cell cortex for multiple generations, and Rax2 was shown to have a half-life exceeding several generations. The persistent inheritance of cortical protein markers would provide a means to couple a cell's history to the future development of a precise morphogenetic form.

  • * To whom correspondence should be addressed. E-mail: chant{at} (J.C.) and atsushi{at}

View Full Text