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Multigenerational Cortical Inheritance of the Rax2 Protein in Orienting Polarity and Division in Yeast

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Science  08 Dec 2000:
Vol. 290, Issue 5498, pp. 1975-1978
DOI: 10.1126/science.290.5498.1975

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Abstract

Diploid yeast cells repeatedly polarize and bud from their poles, probably because of highly stable marks of unknown composition. Here, Rax2, a membrane protein, was shown to behave as such a mark. The Rax2 protein itself was inherited immutably at the cell cortex for multiple generations, and Rax2 was shown to have a half-life exceeding several generations. The persistent inheritance of cortical protein markers would provide a means to couple a cell's history to the future development of a precise morphogenetic form.

  • * To whom correspondence should be addressed. E-mail: chant{at}fas.harvard.edu (J.C.) and atsushi{at}nibh.go.jp(A.F.).

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