News of the WeekNeuroscience

Immune Molecules Prune Neural Links

See allHide authors and affiliations

Science  15 Dec 2000:
Vol. 290, Issue 5499, pp. 2051
DOI: 10.1126/science.290.5499.2051a

You are currently viewing the summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution


In work described on page 2155, a team of neuroscientists suggests that the class I major histocompatibility complex proteins, previously known for their role in controlling immune responses, also play a role in the nervous system. They are necessary for the formation of normal neuronal connections in a visual area of the brain during development, and later in life, they're called into play in the hippocampus, a brain area involved in memory and learning. The work shows a completely unexpected function for the immune system molecules.