PerspectiveNeurobiology

A Stargazer Foretells the Way to the Synapse

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Science  22 Dec 2000:
Vol. 290, Issue 5500, pp. 2270-2271
DOI: 10.1126/science.290.5500.2270

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Summary

How do AMPA receptors that are made in the cytoplasm of excitatory neurons travel to and become localized in the distant postsynaptic membranes of dendrites? Nakagawa and Sheng, in a Perspective, suggest that the answer may lie in the stargazin protein that has now been found to interact with AMPA receptors, guiding them to the postsynaptic membrane.