PerspectiveCELL CYCLE

License Withheld--Geminin Blocks DNA Replication

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Science  22 Dec 2000:
Vol. 290, Issue 5500, pp. 2271-2273
DOI: 10.1126/science.290.5500.2271

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A cell ensures that its genome is replicated only once during its division cycle through a process called licensing. In an enlightening Perspective, Lygerou and Nurse explain how binding of the Geminin protein to Cdt1 blocks the binding of licensing factors to chromatin, inhibiting the onset of S phase ( Wohlschlegel et al. ).