Report

Glycolipid Antigen Processing for Presentation by CD1d Molecules

Science  26 Jan 2001:
Vol. 291, Issue 5504, pp. 664-667
DOI: 10.1126/science.291.5504.664

You are currently viewing the abstract.

View Full Text

Via your Institution

Log in through your institution

Log in through your institution


Abstract

The requirement for processing glycolipid antigens in T cell recognition was examined with mouse CD1d-mediated responses to glycosphingolipids (GSLs). Although some disaccharide GSL antigens can be recognized without processing, the responses to three other antigens, including the disaccharide GSL Gal(α1→2)GalCer (Gal, galactose; GalCer, galactosylceramide), required removal of the terminal sugars to permit interaction with the T cell receptor. A lysosomal enzyme, α-galactosidase A, was responsible for the processing of Gal(α1→2)GalCer to generate the antigenic monosaccharide epitope. These data demonstrate a carbohydrate antigen processing system analogous to that used for peptides and an ability of T cells to recognize processed fragments of complex glycolipids.

  • * Present address: Department of Molecular Microbiology and Immunology, Brown University, Providence, RI 02912, USA.

  • To whom correspondence should be addressed. E-mail: mitch{at}liai.org

View Full Text

Related Content