Review

Protein Dynamics: Implications for Nuclear Architecture and Gene Expression

Science  02 Feb 2001:
Vol. 291, Issue 5505, pp. 843-847
DOI: 10.1126/science.291.5505.843

You are currently viewing the abstract.

View Full Text

Abstract

Studies of nuclear architecture reveal that the dynamic properties of proteins in the nucleus are critical for their function. The high mobility of proteins ensures their availability throughout the nucleus; their dynamic interplay generates an ever-changing, but overall stable, architectural framework, within which nuclear processes take place. As a consequence, overall nuclear morphology is determined by the functional interactions of nuclear components. The observed dynamic properties of nuclear proteins are consistent with a central role for stochastic mechanisms in gene expression and nuclear architecture.

View Full Text

Cited By...