Protein Dynamics: Implications for Nuclear Architecture and Gene Expression

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Science  02 Feb 2001:
Vol. 291, Issue 5505, pp. 843-847
DOI: 10.1126/science.291.5505.843

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Studies of nuclear architecture reveal that the dynamic properties of proteins in the nucleus are critical for their function. The high mobility of proteins ensures their availability throughout the nucleus; their dynamic interplay generates an ever-changing, but overall stable, architectural framework, within which nuclear processes take place. As a consequence, overall nuclear morphology is determined by the functional interactions of nuclear components. The observed dynamic properties of nuclear proteins are consistent with a central role for stochastic mechanisms in gene expression and nuclear architecture.

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