The Sequence of the Human Genome

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Science  16 Feb 2001:
Vol. 291, Issue 5507, pp. 1155
DOI: 10.1126/science.291.5507.1155d

The sequence of the human genome assembled by Venter et al. (p. 1304) was obtained by pursuing a “shotgun strategy” in which the genome was broken into a random set of fragments of known sizes for sequencing. Computer algorithmic methods were then used to assemble the fragments into contiguous stretches that could be assigned to the correct location within the genome. The article (with representations of Fig. 1 as a chart polybagged with the issue and on Science Online) contains the method and documentation of the quality of the reconstructed genome as well as initial looks at the genes and their organization.

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