An Endostatin-Integrin Partnership

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Science  23 Feb 2001:
Vol. 291, Issue 5508, pp. 1451
DOI: 10.1126/science.291.5508.1451c

Endostatin is a cleavage product of an extracellular matrix (ECM) collagen and a potent inhibitor of angiogenesis. Tumor growth relies on the formation of new blood vessels, yet how endostatin achieves its inhibitory effect remains unclear.

Rehn et al. propose that endostatin may act as a ligand for α5-and αv-integrins, endothelial cell adhesion molecules that have been implicated in regulating angiogenesis and tumorigenesis. When presented as an immobilized substrate, endostatins promoted cell adhesion, motility, and survival in an integrin-dependent manner, and also induced downstream signaling events. In contrast, soluble endostatin acted as an integrin antagonist and inhibited these processes. Hence, modulating integrin function may be one means by which endostatins act. — LDC

Proc. Natl. Acad. Sci. U.S.A.98, 1024 (2001).

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