Report

Contribution of Receptor Editing to the Antibody Repertoire

Science  23 Feb 2001:
Vol. 291, Issue 5508, pp. 1541-1544
DOI: 10.1126/science.1056600

You are currently viewing the abstract.

View Full Text

Via your Institution

Log in through your institution

Log in through your institution


Abstract

Receptor editing, clonal deletion, and anergy are the mechanisms by which B cells maintain tolerance to self antigens. To determine the extent to which receptor editing shapes the normal antibody repertoire, we generated an immunoglobulin κ polymorphism that facilitates the detection of editing of immunoglobulin light chains in vivo. We found that B cells are targeted for editing during a 2-hour delay in development at the pre-BII cell stage, and that about 25% of all antibody molecules are produced by gene replacement. These results suggest that receptor editing represents a major force in shaping the antibody repertoire.

  • * Present address: Massey University, Palmerston North, New Zealand.

  • To whom correspondence should be addressed. E-mail: nussen{at}rockvax.rockefeller.edu

View Full Text

Related Content