Variety in the Message

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Science  02 Mar 2001:
Vol. 291, Issue 5509, pp. 1665
DOI: 10.1126/science.291.5509.1665d

Splicing of messenger RNA is critical for protein synthesis and requires binding of the SR family of splicing factors. SR factors are also thought to direct alternative splicing of certain RNAs, leading to changes in the structure and function of the resulting proteins. For the lymphocyte membrane phosphatase, CD45, a variety of splice options are possible, producing isoforms that differentially affect cell signaling.

Wang et al. used conditional deletion of the gene for the SR splice factor, SC35, in mouse T cells, to study how control of splice variation in the RNA encoding CD45 might influence the biology of these lymphocytes. In the absence of SC35, the splicing of CD45 message was altered producing new CD45 isoforms that impaired T cell development. — SJS

Mol. Cell7, 331 (2001).

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