DATA: Raw Rodent Genomes

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Science  02 Mar 2001:
Vol. 291, Issue 5509, pp. 1669
DOI: 10.1126/science.291.5509.1669b

When DNA is fed into a sequencing machine, it doesn't come out as one long string of A's, T's, G's, and C's. Instead, the instruments read short snippets of DNA that then have to be put into their proper order along chromosomes. The international consortium that is working to produce a rough draft of the mouse genome by April is now sending the raw data from each sequencing machine—known as trace data—to public Web databases each week. Researchers can use these 500- to 600-base bits to look for matches with the newly completed human genome—without having to wait for the polished product, which won't be available for months. Sequencers are also archiving trace data from the rat genome and may later add more organisms being analyzed by the “whole-genome shotgun” approach.

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