Moving On

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Science  09 Mar 2001:
Vol. 291, Issue 5510, pp. 1910-1911
DOI: 10.1126/science.1059938

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In the developing embryo, commissural axons migrate from one side of the body, across the midline to the other side under the influence of guidance cues. But how is it that axons can be attracted to the midline by netrin, yet are able to ignore netrin's attractive signal once they have crossed the midline? In his Perspective, Dickson takes us on an axonal odyssey describing the adept ability of commissural axons to change their preferences for guidance cues depending on which side of the midline they are on.