Signaling Antibiotic Resistance in Staphylococci

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Science  09 Mar 2001:
Vol. 291, Issue 5510, pp. 1915-1916
DOI: 10.1126/science.1059671

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For 30 years biologists have studied the molecular machinery of staphylococcal bacteria that renders them resistant to b-lactam antibiotics. In a Perspective, Archer and Bosilevac discuss new findings showing that cleavage of a sensor-transducer protein after it binds to a b-lactam antibiotic results in cleavage of the repressor protein that binds to the blaZ gene. b-Lactamase is then produced and binds to and inactivates the antibiotic.