PerspectiveMolecular Biology

RNP Remodeling With DExH/D Boxes

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Science  09 Mar 2001:
Vol. 291, Issue 5510, pp. 1916-1917
DOI: 10.1126/science.1059682

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The DExH/D proteins are known to have RNA helicase activity, that is, they bind to and unwind double-stranded RNA. As Will and Lührmann explain in their Perspective, these enzymes can also behave as RNPases, disrupting the interactions between RNA and proteins in ribonucleoprotein complexes such as the spliceosome.