Memory T Cells--Local Heroes in the Struggle for Immunity

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Science  23 Mar 2001:
Vol. 291, Issue 5512, pp. 2323-2324
DOI: 10.1126/science.1059984

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Many of the cellular and molecular processes involved in forming and maintaining immunological memory are still unknown. In their Perspective, Mackay and von Andrian discuss new work that tracks the migration of antigen-stimulated memory T cells from the lymphoid tissues to nonlymphoid tissues where they form the first line of defense against pathogens that are reencountered. Memory T cells that remain in the lymphoid tissues constitute the backup team, that comes to the rescue when the nonlymphoid memory T cells become overwhelmed.