PerspectiveStructural Biology

Flipping a Switch

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Science  23 Mar 2001:
Vol. 291, Issue 5512, pp. 2329-2330
DOI: 10.1126/science.1060383

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Proteins are not inert structures but are constantly in motion. In their Perspective, Buck and Rosen describe new experiments that use the power of nuclear magnetic resonance to correlate motions in nitrogen regulatory protein C, a bacterial signaling protein, with its biological activity ( Volkman et al. ).