The Best of Both Worlds?

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Science  23 Mar 2001:
Vol. 291, Issue 5512, pp. 2342
DOI: 10.1126/science.291.5512.2342

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Sugars don't bind as tightly to their targets as other molecules do, making them less desirable drug candidates. Now Ole Hindsgaul has developed what he calls "carbohybrids," molecules containing a sugar portion linked to other organic groups that are simple to make and typically bind more tightly to protein drug targets. The strategy is showing early promise.