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Preferential Localization of Effector Memory Cells in Nonlymphoid Tissue

Science  23 Mar 2001:
Vol. 291, Issue 5512, pp. 2413-2417
DOI: 10.1126/science.1058867

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Abstract

Many intracellular pathogens infect a broad range of host tissues, but the importance of T cells for immunity in these sites is unclear because most of our understanding of antimicrobial T cell responses comes from analyses of lymphoid tissue. Here, we show that in response to viral or bacterial infection, antigen-specific CD8 T cells migrated to nonlymphoid tissues and were present as long-lived memory cells. Strikingly, CD8 memory T cells isolated from nonlymphoid tissues exhibited effector levels of lytic activity directly ex vivo, in contrast to their splenic counterparts. These results point to the existence of a population of extralymphoid effector memory T cells poised for immediate response to infection.

  • * To whom correspondence should be addressed. E-mail: llefranc{at}neuron.uchc.edu

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