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Extension of Life-Span by Loss of CHICO, a Drosophila Insulin Receptor Substrate Protein

Science  06 Apr 2001:
Vol. 292, Issue 5514, pp. 104-106
DOI: 10.1126/science.1057991

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Abstract

The Drosophila melanogaster gene chicoencodes an insulin receptor substrate that functions in an insulin/insulin-like growth factor (IGF) signaling pathway. In the nematode Caenorhabditis elegans, insulin/IGF signaling regulates adult longevity. We found that mutation of chicoextends fruit fly median life-span by up to 48% in homozygotes and 36% in heterozygotes. Extension of life-span was not a result of impaired oogenesis in chico females, nor was it consistently correlated with increased stress resistance. The dwarf phenotype ofchico homozygotes was also unnecessary for extension of life-span. The role of insulin/IGF signaling in regulating animal aging is therefore evolutionarily conserved.

  • * To whom correspondence should be addressed. E-mail: david.gems{at}ucl.ac.uk

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