PerspectiveMolecular Biology

The Histone Modification Circus

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Science  06 Apr 2001:
Vol. 292, Issue 5514, pp. 64-65
DOI: 10.1126/science.1060791

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The histone proteins that constitute the nucleosomes of chromatin around which yards of DNA are wrapped undergo a series of chemical modifications during gene activation and gene silencing. In a Perspective, Berger discusses new results ( Nakayama et al.) that elucidate the sequence of reactions that modify histone H3 and how these modifications translate into gene silencing in fission yeast.