Research Article

Control of a Mucosal Challenge and Prevention of AIDS by a Multiprotein DNA/MVA Vaccine

Science  06 Apr 2001:
Vol. 292, Issue 5514, pp. 69-74
DOI: 10.1126/science.292.5514.69

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Heterologous prime/boost regimens have the potential for raising high levels of immune responses. Here we report that DNA priming followed by a recombinant modified vaccinia Ankara (rMVA) booster controlled a highly pathogenic immunodeficiency virus challenge in a rhesus macaque model. Both the DNA and rMVA components of the vaccine expressed multiple immunodeficiency virus proteins. Two DNA inoculations at 0 and 8 weeks and a single rMVA booster at 24 weeks effectively controlled an intrarectal challenge administered 7 months after the booster. These findings provide hope that a relatively simple multiprotein DNA/MVA vaccine can help to control the acquired immune deficiency syndrome epidemic.

  • * Present address: Department of Microbiology, University of Toronto, Toronto, Ontario, Canada M5G 1X5.

  • Present address: MIT Center for Cancer Research, Cambridge, MA 02139, USA.

  • To whom correspondence should be addressed. E-mail: hrobins{at}

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