A Kinase to Dampen the Effects of Cocaine?

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Science  13 Apr 2001:
Vol. 292, Issue 5515, pp. 236-237
DOI: 10.1126/science.292.5515.236

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Chronic exposure to cocaine results in long-term changes in the central nervous system (CNS). In their Perspective, Gupta and Tsai discuss new results, reported elsewhere, that elucidate the signaling pathways that promote and dampen down the effects of chronic cocaine on the CNS. They explain the part played by a cyclin-dependent kinase (Cdk5), which is switched on by the DFosB transcription factor and regulates PKA-dependent signaling pathways, resulting in a dampening of the effects of chronic cocaine.