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Regulation of Longevity and Stress Resistance by Sch9 in Yeast

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Science  13 Apr 2001:
Vol. 292, Issue 5515, pp. 288-290
DOI: 10.1126/science.1059497

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Abstract

The protein kinase Akt/protein kinase B (PKB) is implicated in insulin signaling in mammals and functions in a pathway that regulates longevity and stress resistance in Caenorhabditis elegans. We screened for long-lived mutants in nondividing yeastSaccharomyces cerevisiae and identified mutations in adenylate cyclase and SCH9, which is homologous to Akt/PKB, that increase resistance to oxidants and extend life-span by up to threefold. Stress-resistance transcription factors Msn2/Msn4 and protein kinase Rim15 were required for this life-span extension. These results indicate that longevity is associated with increased investment in maintenance and show that highly conserved genes play similar roles in life-span regulation in S. cerevisiae and higher eukaryotes.

  • * To whom correspondence should be addressed. E-mail: vlongo{at}usc.edu

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